表面扩散系数在口腔恶性淋巴瘤差异诊断中的实用性
Hideaki Hirai1, Yutaka Nikkuni2, Ryota Kobayashi3
1Division of Oral and Maxillofacial Surgery, Faculty of Dentistry ＆ Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JPN.
Cureus
|December 19, 2025
概括
表面扩散系数 (ADC) 值可以帮助区分口腔恶性淋巴瘤 (ML) 与状细胞癌 (SCC) 和唾液腺癌 (SGC). 较低的ADC值强烈表明ML,有助于早期诊断和管理.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 口腔恶性淋巴瘤 (ML) 的诊断是具有挑战性的,因为其与其他口腔病变的临床相似性.
- 非霍奇金淋巴瘤 (NHL) 是口腔ML的主要类型.
- 扩散权重的MRI和明显扩散系数 (ADC) 值显示了差异诊断的潜力.
研究的目的:
- 评估ADC值在区分口腔ML与状细胞癌 (SCC) 和唾液腺癌 (SGC) 中的诊断效用.
主要方法:
- 追溯分析了11个ML,35个SCC和19个SGC案件.
- 用3.0 T扫描仪进行的MRI.
- 临床数据和ADC值的分析.
主要成果:
- 单纯基于临床评估的ML病例经常被错误分类.
- 与SCC (1.21 ± 0.14) 和SGC (1.30 ± 0.27) (P < 0.0001) 相比,ML显示了明显较低的ADC值 (0.67 ± 0.13 × 10−3 mm2/s).
- 在0.87 × 10−3 mm2/s的ADC切线下,实现了100%的灵敏度和98.2%的ML检测特异性 (AUC:0.99).
结论:
- 评估ADC可以帮助早期怀疑口服ML.
- 将ADC值集成到诊断工作流程中可以改善与癌症的差异化.
- 这有助于通过早期识别和适当的活检策略及时管理.
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