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codonGPT:基于生成语言模型的强化学习可以实现可扩展的mRNA设计

Binita Rajbanshi1, Anuj Guruacharya1

  • 1Nanil Therapeutics Inc., Canada.

Nucleic acids research
|December 19, 2025
PubMed
概括

我们开发了codonGPT,这是用于信使RNA (mRNA) 设计的生成语言模型. 该模型与强化学习 (RL) 结合,优化mRNA序列,以改善生物应用中的表达,稳定性和GC含量.

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