HbA1c的变化和发生心力衰竭的风险:系统性审查和元分析
Guo Mujiafu Qiao Longbatu1, La Xinamujila2, Bao Burie3
1Cardiology Department, International Mongolian Hospital of Inner Mongolia, Hohhot, China; College of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao, China.
Biomolecules & biomedicine
|December 19, 2025
概括
糖化血红蛋白 (HbA1c) 的高访问到访问的变化与心力衰竭 (HF) 的风险增加有关. 维持稳定的血糖控制对于2型糖尿病患者来说至关重要,以减少HF发病率.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 糖化血红蛋白 (HbA1c) 的访问到访问的变化表明血糖控制的不稳定性.
- 这种不稳定可能会导致心血管并发症,包括心力衰竭 (HF).
- 需要进一步阐明HbA1c变异性和发生性HF风险之间的准确关系.
研究的目的:
- 量化访问对访问的HbA1c变异性与成人发生HF风险之间的关联.
- 综合了关于这个主题的多项研究的证据.
- 为了突出血糖控制稳定的预后意义.
主要方法:
- 使用PubMed,Embase和Web of Science的数据进行了系统的元分析.
- 包括的研究是观察性或后期分析,检查HbA1c变异性和HF风险.
- 使用随机效应模型将危险比率 (HR) 和95%置信区间 (CI) 结合起来.
主要成果:
- 分析了包括342,123名参与者的9项研究.
- 高HbA1c变异性与高血压风险增加有显著的关联 (汇总HR=1.78).
- 在灵敏度和子组分析中观察到一致的结果,在潜在队列中存在更强的关联.
结论:
- 较大的访问到访问的HbA1c变异性与发生性心力衰竭的风险更高有关.
- 稳定的长期血糖控制对于降低2型糖尿病患者的HF风险很重要.
- HbA1c的变异性是心血管并发症的潜在预后标志物.
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