人参提取物改善突触弹性:健康的认知衰老的关键因素
Michael F Almeida1,2,3,4, Morgan C Pait1, Katherine M Rentschler1
1Biotechnology Research and Training Center, University of North Carolina-Pembroke, Pembroke, North Carolina, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 19, 2025
概括
帕纳克斯昆奎福利乌斯 (PanQ) 提取物增强了自-溶酶体通路 (ALP) 和甲素B (CatB),增强了老老鼠的突触功能和认知表现.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 营养科学 营养科学
背景情况:
- 自-溶酶体通路 (ALP) 的破坏会损害蛋白质稳定,导致与年龄相关的蛋白质病变.
- 饮食干预措施在改善认知健康和降低阿尔茨海默病风险方面表现有前途.
研究的目的:
- 研究植物提取物对自-溶酶体通路 (ALP) 和甲素B (CatB) 活性的影响.
- 评估Panax quinquefolius (PanQ) 提取物在增强老化模型中的认知功能和突触弹性方面的潜力.
主要方法:
- 河马拓展剂被用来选植物提取物,以检测它们增强甲素B (CatB) 的能力.
- Panax quinquefolius (PanQ) 提取物对老老鼠的突触蛋白,自标志物 (LC3-II) 和认知表现的影响进行了测试.
- 在溶酶体应激模型中评估了突触弹性.
主要成果:
- 帕纳克斯昆奎福利乌斯 (PanQ) 提取物显著增加了活性甲素B (CatB) 水平.
- PanQ治疗与突触蛋白水平升高和自标志物LC3-II.II相关.
- 在老老鼠中,PanQ增强了突触性和提高了认知表现.
结论:
- 帕纳克斯昆奎福利乌斯 (PanQ) 增强了自-溶酶体通路 (ALP),使蛋白质稳定网络参与认知维护.
- 突触弹性是饮食成分影响的关键因素,影响认知健康.
- PanQ显示出作为与年龄相关的认知衰退的饮食干预的潜力.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
512
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
512
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
175
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
175
01:30Cognitive Development During Adulthood
745
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
745
01:26Aging
566
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
566
01:23Role of Neurotransmitters in Memory
2.4K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.4K
01:15Drug Dosing: Geriatric Patients
209
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
209