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恢复男性生育能力的道路使用体外衍生生殖细胞
Tiago Macedo1, João Pedro Alves-Lopes1
1Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Human reproduction update
|December 19, 2025
概括
人类诱导的多能干细胞 (hiPSCs) 可以分化为男性生殖细胞,为不孕症治疗提供希望. 研究正在推进人类原始生殖细胞样细胞 (hPGCLCs) 的定义协议,并解决临床应用的伦理考虑.
科学领域:
- 生殖医学 生殖医学
- 干细胞生物学 干细胞生物学
- 发展生物学 发展生物学
背景情况:
- 人类诱导的多能干细胞 (hiPSCs) 为生殖医学提供了重大机会,特别是对于面临不孕症的男性来说.
- 以前试图从干细胞中获得人类生殖细胞的尝试面临着效率,表征和标准化方面的挑战.
- 最近定义的协议现在允许对转录组和表观遗传学验证的人类原始生殖细胞样细胞 (hPGCLCs) 的规范.
研究的目的:
- 审查区分男性生殖细胞与人类多能干细胞 (hPSCs) 的努力和挑战.
- 专注于对hPGCLC规范进行定义和验证的协议.
- 针对基于hiPSC的生育策略的临床应用的安全性和伦理考虑.
主要方法:
- 使用PubMed,Scopus和Web of Science进行了全面的文献搜索.
- 关键词包括"干细胞"",人类多能干细胞"",不孕症"",生殖系"",精子生成"和"原始生殖细胞".
- 专注于男性生殖系差异化的研究是优先考虑的,排除了专门针对女性的研究.
主要成果:
- 来自hPSCs的生殖细胞衍生协议显示,从早期的,不那么标准化的方法到最近定义的,验证的方法的明显进展.
- 在体外成熟的hPGCLC中取得了显著进展,重复了男性胚胎生殖系的发展.
- 来自不孕男性的hiPSCs通常保留了生殖线分化的能力,尽管超越hPGCLC阶段的成熟是有限的.
结论:
- 从不育的患者中产生hiPSC并将其分化为hPGCLC的能力支持hiPSC衍生的精子干细胞 (SSC) 在治疗中的潜力.
- 这些进展需要积极讨论对负责任的临床实施的伦理,监管和社会影响.
- 预计将有进一步的突破,可能会导致临床上适用的生育恢复策略.
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