脑静脉血栓症后的认知障碍:系统性审查和元分析
Luisa Medeiros Visentini1, Gustavo Nascimento de Medeiros2, Aluisio D'lucas Alves E Gomes3
1University of Western São Paulo, Presidente Prudente, Brazil.
概括
认知障碍影响19-29%的脑静脉血栓症 (CVT) 幸存者,影响记忆和执行功能. 这凸显了需要在CVT患者的功能恢复之外进行全面评估的必要性.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 大脑静脉血栓 (CVT) 主要影响年轻人,特别是女性,并且通常与其他类型的中风相比具有更好的功能结果有关.
- 持续培训的认知后果仍然不太清楚,需要进一步研究.
研究的目的:
- 系统地审查和进行关于CVT患者认知障碍的流行率和特征的元分析.
- 评估CVT对认知功能的影响,包括记忆,执行功能和视觉空间领域.
主要方法:
- 按照PRISMA指南进行了系统审查和元分析,搜索了PubMed,Embase和Cochrane数据库,直到2025年5月.
- 包括11项观察性研究和1项随机临床试验,涉及801名CVT后患者,随访时间至少为6个月.
- 使用随机效应通用线性混合模型计算了聚合流行率估计,使用I2统计评估异质性.
主要成果:
- 持续训练后认知障碍的综合流行率在19.25% (偏差风险低) 到29.20% (总体分析) 之间.
- 在39.21%的患者中报告了记忆丧失,在35.94%的患者中影响了执行功能和视觉空间领域.
- 在功能独立患者 (mRS 0-2) 的28.6%至36.3%观察到认知障碍.
结论:
- 认知障碍影响了大约五分之一到三分之一的CVT幸存者,即使是那些功能障碍最小的人.
- 这些发现强调了在CVT患者中评估经过修改的兰金尺度 (mRS) 之外的认知恢复的重要性.
- 综合后续护理规划应整合认知评估,以改善患者的治疗结果.
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