手术后疼痛:不断发展的药物治疗方法和挑战
Mohammad Khudirat1, Loay Allafy1, Bhuvrit Raj Dhakal1
1Center for Outcomes Research and Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, UTHealth, Houston, TX, USA.
Expert opinion on pharmacotherapy
|December 19, 2025
概括
有效的术后疼痛管理仍然是一个挑战. 本综述探讨了药理选择和实施障碍,以改善患者的康复和减少慢性疼痛风险.
科学领域:
- 麻醉学和疼痛管理
- 药理学 药理学是指药理学的学科.
- 临床实践 临床实践
背景情况:
- 有效的术后疼痛控制对于患者的康复和预防慢性疼痛至关重要.
- 采用多种模式的止痛药,但实施不一致.
- 系统,临床和机构障碍阻碍了最佳的疼痛管理.
研究的目的:
- 审查手术后疼痛的当前和新兴药理学药物.
- 批判性地评估新型配方和辅助疗法.
- 确定先进疼痛管理策略的临床实施障碍.
主要方法:
- 对治疗术后疼痛的药理学药物的系统审查.
- 对已知药物的评估 (乙氨基,NSAID,胺).
- 对新型配方和辅助剂 (如维生素C,杜洛西丁) 的评估.
主要成果:
- 一个不断扩大的药理学武器库存在,包括在减少阿片类药物使用方面显示出有前途的新药.
- 较新的药物显示出改善恢复的潜力.
- 临床实施受到成本,提供者熟悉度和现实世界的证据不足的限制.
结论:
- 尽管有前途的新药,但手术后疼痛的广泛采用受到成本和数据限制的阻碍.
- 弥合创新与实践之间的差距需要协调的研究,教育和政策努力.
- 解决实施障碍是推动术后疼痛管理的关键.
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