在肺炎后的乌干达人中,一氧化碳异常扩散能力的预测因素 患有和没有艾滋病毒的乌干达人
Katerina L Byanova1, Jessica Fitzpatrick2, Josephine Zawedde3
1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.
肺功能异常 (一氧化碳的扩散能力) 在乌干达肺炎后很常见. 结核病和吸烟等风险因素在艾滋病毒感染者和未感染者之间存在差异,这凸显了对量身定制护理的需要.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 一氧化碳 (DLco) 的异常扩散能力在艾滋病毒感染者 (PWH) 中普遍存在,并与死亡率有关.
- 关于东非的DLco,特别是乌干达的数据有限.
- 了解PWH和没有艾滋病毒的人 (PWoH) 的DLco对于该地区的公共卫生至关重要.
研究的目的:
- 在乌干达成年人中描述异常DLco的患病率和危险因素.
- 为了比较PWH和PWoH之间的DLco预测器.
- 为了在这个人群中为肺部健康提供有针对性的干预措施.
主要方法:
- 在乌干达坎帕拉的艾滋病毒感染和没有艾滋病毒感染的成年人肺炎后的横截面分析.
- 使用符合ATS/ERS的DLco测量.
- 采用多变量回归模型,包括根据艾滋病毒状态进行分层分析,以确定异常DLco.的预测因子.
主要成果:
- 在447名参与者中,异常DLco的患病率为21.7%.
- 艾滋病毒,过去的细菌性肺炎和结核病 (TB) 与较低的DLco相关.
- 结核病预测PWH和PWoH的DLco较低;吸烟预测PWoH的DLco较低,而工作烟雾暴露与PWH的DLco异常有关.
结论:
- 异常DLco是乌干达成年人肺炎后的一个重要并发症.
- 异常DLco的预测因子根据HIV血清状况而有所不同.
- 需要进一步的纵向研究来了解DLco轨迹和相关的发病率.
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