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Updated: Jan 8, 2026

Quaternary Structure Modeling Through Chemical Cross-Linking Mass Spectrometry: Extending TX-MS Jupyter Reports
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使用SILCS-xTAC的PROTAC三元复合体作为集体的计算建模

Erik B Nordquist1, Mingtian Zhao1, Wenbo Yu1,2,3

  • 1Computer Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, Baltimore, Maryland 21201, United States.

Journal of chemical information and modeling
|December 19, 2025
PubMed
概括

针对蛋白质溶解的嵌合体 (PROTACs) 是一种新的治疗方法. 一种新的计算方法,SILCS-xTAC,准确地预测了PROTAC结合,并有助于设计具有挑战性的蛋白质标的药物.

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