氧化在毒理学案例中的兴起:没有笑话
Amanda L D'Orazio1, Jolene J Bierly1, Kari M Midthun1
1NMS Labs, Horsham, PA, USA.
Journal of analytical toxicology
|December 19, 2025
概括
氧化 (N2O) 的滥用正在增加,这给分析带来了挑战. 法医样本的新处理指南,包括有限的头部空间和避免重复测试,提高了驾驶和死后病例的检测率.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 吸入剂的滥用 吸入剂的滥用
背景情况:
- 氧化 (N2O) 或"笑气"越来越多地被用于娱乐目的.
- 它的麻醉性质会引起高兴和镇静,但副作用包括缺氧.
- 越来越多的N2O滥用需要加强法医测试能力.
研究的目的:
- 评估法医案例工作中氧化 (N2O) 的分析检测挑战.
- 确定可疑N2O暴露的最佳样本采集和处理程序.
- 提高在药物影响下驾驶 (DUID) 和死后 (PM) 病例的检测率.
主要方法:
- 从2022年1月到2025年9月,使用头空间气体染色学质谱法 (HS-GC-MS) 分析了超过1700个N2O病例.
- 在各种生物基质 (血液,大脑,肝脏,肺,尿液) 中研究N2O度.
- 评估样品处理技术,包括容器类型,头部空间体积和重复测试效应.
主要成果:
- 在DUID和PM案例工作中观察到N2O测试请求和阳性率的增加.
- 在血液,大脑,肝脏,肺部和尿液样本中证实了阳性N2O检测.
- 在重复测试时发生了显著的分析物度损失,突出了分析前的漏洞.
结论:
- 在吸入的情况下,预分析和分析因素对于准确的N2O检测至关重要.
- 推的处理方法包括尽量减少头部空间,使用玻璃容器,避免转移,并限制重复测试.
- 优先进行N2O测试并考虑定性,一次性分析可以提高检测成功率.
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