神经发育障碍中的跨诊断行为现象和并发性胃肠道症状:一项探索性研究
Shane Cleary1,2, Sarah Asbury1, Russell J Schachar3,4
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
概括
在神经发育障碍 (NDD) 中,基于行为,而不仅仅是诊断,识别子组是关键. 具有更严重的行为特征的儿童,包括自闭症谱系障碍 (ASD) 和注意力缺陷多动性障碍 (ADHD),患上胃肠道症状的比率更高.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 遗传学 是一个
背景情况:
- 神经发育障碍 (NDD),如自闭症谱系障碍 (ASD) 和注意力缺陷多动性障碍 (ADHD),存在着不同的行为模式和重叠的症状.
- 了解这些变异对于有效的诊断和干预至关重要.
研究的目的:
- 在被诊断为NDD的儿童队伍中识别基于行为的子组.
- 调查这些子组中胃肠道 (GI) 症状和行为表型之间的关系.
主要方法:
- 在1716名参与者的行为数据 (典型的发展,ASD,ADHD) 上使用异质混合模型 (HMM).
- 分析了来自安大略省神经发育障碍 (POND) 网络的数据.
- 检查了 GI 症状在已识别的行为集群中的流行率.
主要成果:
- 确定了六个不同的行为集群.
- 五个集群包括患有混合诊断的个体 (通常是发展,ASD,ADHD).
- 一个集群,只包含患有ASD和ADHD的参与者,表现出最严重的行为表型和显著更高的胃肠道症状患病率.
结论:
- 行为维度,而不是仅仅是诊断标签,对于划分NDD子组至关重要.
- 严重的行为表型和胃肠道症状之间的强烈关联凸显了肠-大脑轴在NDD中的潜在作用.
- 对肠-大脑轴信号通路的进一步研究可能会阐明NDD行为形状的个体差异背后的生物学机制.
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