FcμR和IgM介导的补充激活合作增强幽默免疫力
Zichao Wen1, Lulu Dong1, Jun Liu1
1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
European journal of immunology
|December 19, 2025
概括
分泌IgM通过两个途径增强IgG反应:FcμR参与和补充激活. 这些独特的协同机制对于B细胞激活,生殖中心形成和抗体产生至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 分泌IgM对于强大的抗原特异性IgG反应至关重要.
- 免疫增强IgM作用的机制,特别是Fc受体 (FcμR) 参与和补体激活,尚未完全理解.
- 在B细胞分化中的FcμR和补充途径之间的相互作用和冗余性仍然不清楚.
研究的目的:
- 阐明FcμR的独特和合作作用,并补充IgM介导的幽默免疫的途径.
- 研究这些途径在B细胞分化的不同阶段的功能.
- 定义IgM在体内增强B细胞反应的分子机制.
主要方法:
- 使用了缺少FcμR的小鼠和Cμ13的小鼠,并使用了补充-非激活IgM.
- 生成FcμR-/-Cμ13双突变小鼠,以评估结合途径的缺陷.
- 分析了T-依赖性免疫反应,B细胞激活,生殖中心形成和血细胞分化.
主要成果:
- FcμR和补充通路在IgG生产中起着非冗余的协同作用.
- 这两种途径对于早期B细胞激活,扩张,类开关重组,生殖中心形成和血细胞分化都至关重要.
- 补充激活对于生殖中心B细胞的增殖和亲和成熟至关重要,而FcμR增强了B细胞受体信号传递.
结论:
- 两种不同的,合作性IgM介导的机制,涉及FcμR和补充,调节幽默免疫.
- FcμR信号增强了纯粹的B细胞激活,而补体激活则驱动了生殖中心的反应.
- 这些发现澄清了IgM如何通过协同途径协调B细胞分化和抗体产生.
相关概念视频
Complement System
9.5K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.5K
Humoral Immune Responses
83.2K
Overview
83.2K
Antibody Actions
2.3K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.3K
Antigens Involved in Adaptive Immunity
1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
B Cell Activation and Differentiation
15.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.8K
Cell-mediated Immune Responses
83.3K
Overview
83.3K


