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Updated: Jun 15, 2026

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
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Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

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开发一种基于肺上芯片的急性吸入毒性测试方法

Ga Eun Kim1, Yubin Han2, In Jae Bang2

  • 1College of Pharmacy, Korea University, Sejong, Republic of Korea. haryongkim@korea.ac.kr.

Lab on a chip
|December 19, 2025
PubMed
概括

这项研究开发了一种优化的肺上芯片 (LOC) 模型,用于急性吸入毒性测试. 微流体装置成功预测了毒性,为动物试验提供了一个有希望的替代方案.

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Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms10:30

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相关概念视频

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...