伦瓦替尼在患有晚期甲状腺癌的患者中具有免疫调节作用
Prashant Changoer1, Chunying Peng1, Pepijn van Houten1
1Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, the Netherlands.
Cancer immunology, immunotherapy : CII
|December 19, 2025
概括
伦瓦提尼布是一种用于甲状腺癌的氨酸激酶抑制剂,通过改变免疫细胞群和细胞因子配置,广泛影响免疫系统. 这项研究揭示了伦瓦替尼布的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺癌 (TC) 的发病包括与瘤相关的炎症.
- 铁氨酸激酶抑制剂 (TKIs),如伦瓦提尼布,可以调节免疫系统.
- 伦瓦提尼布已批准用于治疗晚期非骨髓性甲状腺癌.
研究的目的:
- 评估伦瓦提尼布在甲状腺癌患者的免疫调节作用.
- 调查伦瓦替尼对髓状细胞 (包括单细胞) 的影响.
- 为了探索伦瓦提尼布对瘤细胞的直接作用.
主要方法:
- 从lenvatinib治疗和未治疗的TC患者 (横截面和纵向队列) 的周围血液的免疫分析.
- 分析包括细胞子集计数,蛋白质组分析和ex vivo细胞因子检测.
- 评估单细胞代谢活动,活性氧物种 (ROS) 生产和健康捐献者的细胞化;TPC-1细胞系分析.
主要成果:
- 伦瓦替尼治疗改变了免疫细胞群 (淋巴细胞增加,中性粒细胞减少) 并调节了炎症蛋白质组.
- 活体和体内分析显示,伦瓦提尼布重编程了单细胞细胞因子的产生,并影响了周围血液单核细胞 (PBMC) 的反应.
- 伦瓦替尼对单细胞代谢产生了影响 (降低糖解,增加ROS) 和改变了瘤细胞表型 (上调的MHC I类,PD-L1,CD40).
结论:
- 伦瓦替尼在TC患者中具有广泛的免疫调节作用,影响免疫细胞分布和细胞因子信号传递.
- 该药物影响单细胞功能和瘤细胞特征,表明多方面的免疫活动.
- 这些发现提供了关于伦瓦替尼的机制的见解,以及在TC治疗中新的治疗策略的潜力.
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