古代谷物面粉的消费作为一种新的治疗方法,用于刺激性肠综合征
Samantha Maurotti1, Yvelise Ferro2, Elisa Mazza3
1Department of Clinical and Experimental Medicine, University "Magna Græcia" of Catanzaro, 88100, Catanzaro, Italy.
由古谷物制成的功能意大利面显著降低了患者的刺激性肠综合征 (IBS) 症状. 这种饮食干预也降低了炎症标志物,这表明了改善IBS患者肠道健康和生活质量的自然方法.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 古代谷物因其可持续性和营养益处而受到越来越多的关注.
- 与现代谷物相比,Triticum monococcum和麦提供了更好的消化能力.
- 这项研究调查了功能意大利面在治疗刺激性肠综合征 (IBS) 的潜力.
研究的目的:
- 评估功能意大利面 (FP) 在缓解IBS症状方面的有效性.
- 评估FP对肠道炎症和氧化应激的影响.
- 探索IBS管理的天然饮食干预措施.
主要方法:
- 42名IBS患者在4周内食用了传统的无质意大利面或FP (麦和麦).
- 刺激性肠综合征严重性评分 (IBS-SSS) 在干预前和后进行测量.
- 在体外研究中评估了功能性意大利面提取物 (FPE) 对Caco-2和T84细胞中的炎症标志物的影响.
主要成果:
- 与对照组相比,FP患者的IBS-SSS得分显著降低 (-153比-83,p=0.044).
- 83%的FP消费者报告了临床显著的症状减少 (IBS-SSS ≥100) 与对照组的35%相比 (p=0.004).
- 在体外,FPE降低了pErk1/2和NF-κB通路的调节,减少了炎症和氧化应激标志物.
结论:
- 用古老的谷物丰富的功能意大利面显示出增强肠道健康的希望.
- 这种饮食方法可以通过减轻炎症和氧化应激减轻IBS症状.
- 基于古谷物的功能意大利面提供了一种自然而有效的替代方案,可以改善IBS患者的生活质量.
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