右心室和双心室CMR菌株分析检测乳腺癌治疗后心肌功能障碍
Destina Gizem Aydemir1, Isabel Molwitz2, Antonia Beitzen-Heineke3
1Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. d.aydemirhoffaerber@uke.de.
European radiology
|December 19, 2025
概括
乳腺癌的抗环素化疗可能会损害心脏,影响右心室 (RV) 和心房. 减少的RV全球纵向菌株 (GLS) 和双心水库菌株可能表明早期的亚临床心脏毒性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 与癌症治疗相关的心脏功能障碍 (CTRCD) 是一个重大问题.
- 人环素化疗是一种常见的乳腺癌治疗方法,与心脏毒性有关.
- 化疗对右心室 (RV) 和心房功能的影响尚未完全理解.
研究的目的:
- 为了研究乳腺癌患者接受 antracycline 化疗的心脏毒性.
- 使用心血管磁共振特征追踪 (CMR-FT) 分析RV和双心功能.
- 为了识别亚临床心脏毒性的早期标志物.
主要方法:
- 对38名接受 antracycline 化疗的女性乳腺癌患者进行前性研究.
- 心血管磁共振 (CMR) 成像在基线和12个月后期进行.
- 功能跟踪 (FT) 用于评估RV全球纵向应变 (GLS),辐射 (GRS) 和周围应变 (GCS),以及双心水库,助推器和导管应变.
主要成果:
- 在化疗后,RV GLS显著下降 (-25.2%至-20.6%,p<0.001).
- 左心房 (LA) 和右心房 (RA) 的储压力显著减少 (LA:p=0.005,RA:p=0.019).
- 没有观察到RV GRS,GCS或心房助推器/导管菌株的显著变化.
结论:
- 癌症治疗的心脏毒性不仅影响左心室,还影响RV和心房.
- 降低RV GLS和双心水库菌株是潜在的亚临床心脏毒性的早期指标.
- 常规评估RV GLS和双心水库菌株可能有助于检测乳腺癌患者的心脏毒性.
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