雷诺现象中的素基因相关抗体:基于真实数据和药物基因网络分析的不成比例性研究
Haibin Zhu1, Minghua Ma1, Weiwei Tian1
1Department of Pharmacy, Yangpu Hospital, School of Medicine, Tongji University, 200090, Shanghai, China.
Naunyn-Schmiedeberg's archives of pharmacology
|December 19, 2025
概括
素基因相关 (CGRP) 抗剂可能构成雷诺现象 (RP) 的风险. PI3K/AKT通路与非小分子诱导的RP有关,因此需要对患者进行监测.
科学领域:
- 药物监督 药物监督 药物监督
- 计算生物学 计算生物学
- 分子医学是分子医学.
背景情况:
- 素基因相关 (CGRP) 抗剂越来越多地用于偏头痛治疗.
- 潜在的不良事件,包括雷诺现象 (RP),需要彻底调查.
- 了解与CGRP对抗剂相关的RP背后的机制对于患者的安全至关重要.
研究的目的:
- 调查与CGRP抗剂相关的RP风险.
- 阐明将CGRP对抗剂与RP联系起来的潜在分子机制.
- 将现实世界的不良事件数据与药物基因网络分析相结合.
主要方法:
- 对FDA不良事件报告系统 (FAERS) 数据的不成比例性分析 (2018年第二季度2025年第一季度).
- 药物-基因网络分析,包括使用STRING数据库构建蛋白质-蛋白质相互作用 (PPI) 网络.
- 基因和基因组的京都百科全书 (KEGG) 路径丰富分析使用R软件.
主要成果:
- 确定了149份与CGRP抗剂与RP相关的不良事件报告,涉及7种药物.
- 弗雷曼祖马布在四种分析方法中表现出最强烈的不良事件信号.
- PI3K/AKT信号通路被确定为非小分子CGRP抗剂诱导RP的关键机制,AKT1,EGFR和ERBB2被突出显示为rimegepant的关键节点.
结论:
- CGRP抗剂与雷诺现象的潜在风险有关.
- PI3K/AKT通路是非小分子CGRP对抗剂诱导的RP的重要潜在机制.
- 建议对使用CGRP抗体的患者进行定期RP监测,特别是那些患有先前存在的血管疾病的患者.
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