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使用分区流体结构相互作用框架对非均动脉的血液动力学分析

Mishal Raza-Taimuri¹, Ian Y Chen², Hamid Sadat³

¹Department of Mechanical Engineering, University of North Texas, Denton, TX, USA.

Cardiovascular engineering and technology

|December 19, 2025

概括

大动脉膜中不均的化显著改变了血液流动和力学. 目前的诊断方法难以预测化严重程度,只有有效孔径面积和最大开口比率才是可靠的.

科学领域:

心血管研究研究心血管研究
生物医学工程生物医学工程
计算流体动力学的流体动力学.

背景情况:

性大动脉病 (CAVD) 涉及逐渐的大动脉结石化,导致狭窄和心脏功能受损.
现有的计算流体动力学 (CFD) 研究通常假定均化,这并不反映临床现实.
当前的诊断技术可能无法准确评估不均化的影响.

研究的目的:

将CFD模拟扩展到模拟非均化的大动脉门.
在非均的化条件下评估临床方法的诊断准确性.

主要方法:

进行了高保真性流体结构相互作用 (FSI) 模拟.
使用来自CT图像的患者特定的门模型.
不统一的化通过在不同严重程度的不同叶片弹性来模拟.

主要成果:

不均的化增加了最大喷射速度 (35-50%) 和跨膜压力梯度 (150-170%).
观察到流流失,流量分离和墙壁剪切应力波动的显著变化.
有效孔面积 (EOA) 和最大开口比 (MOR) 被确定为化严重程度的可靠预测指标.

结论:

不均的化严重影响大动脉的血液动力学和叶片力学.
增加化严重程度导致流动模式和生物力学反应发生显著变化.
该研究强调需要改进诊断工具,以更好地管理CAVD.

关键词:

大动脉的化化.在 CFD 交易中,我们可以看到 CFD.流体结构的相互作用.血液动力学血液动力学

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