在患有肝外门静脉阻塞的儿科患者中,凝血概况和血小板计数
Gabriela Barbosa Unger1, Roberta Vacari de Alcantara1, Maria Angela Bellomo Brandão1
1Universidade Estadual de Campinas, Campinas, SP, Brazil.
概括
患有肝外门静脉阻塞 (EHPVO) 的儿科患者经常患有贫血和血栓塞缩症. 在EHPVO患者的脊髓切除术改善了血小板计数和凝血参数 (R和INR).
科学领域:
- 儿科胃肠病学和肝病学
- 血液学 血液学 血液学
- 凝血障碍 凝血障碍 凝血障碍
背景情况:
- 肝外门静脉阻塞 (EHPVO) 是儿童门高血压的一个重要原因.
- 小儿EHPVO患者的凝血异常和血液学变化很常见.
- 了解这些变化对于管理EHPVO和预防并发症至关重要.
研究的目的:
- 调查诊断为EPHVO的儿科患者的凝血异常和血液计量指数.
- 为了比较治疗前和治疗后的血液学和凝血参数,包括脊髓切除术.
主要方法:
- 一项对93名儿科EHPVO患者 (1991年1月至2023年12月) 的回顾性和纵向性研究.
- 患者被分为三个组:没有手术的EHPVO (G1),没有脊髓切除术的EHPVO (G2) 和脊髓切除术的EHPVO (G3).
- 从医疗记录中收集的数据包括凝血参数 (R,INR) 和血液计量指数 (血小板,贫血).
主要成果:
- 在入院时,观察到长时间R (52.32%),INR (26.8%),贫血 (67.7%) 和血小板缺血 (70.45%) 的高患病率.
- 在切除组 (G3) 中,与入院相比,在最后的随访中,R和INR的显著降低和血小板的显著增加.
- 在非手术组 (G1) 中没有观察到R,INR或血小板的显著变化.
结论:
- 儿科EHPVO患者在入院时表现出高贫血率,血小板减少和延长凝血时间.
- 在EHPVO患者的脊髓切除术导致血小板数量的改善和凝血参数 (R和INR) 的正常化.
- 观察到的凝血异常可能与脏功能障碍有关,而不是洞穴瘤中的因子消耗.
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