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Updated: Jan 8, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

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DNMT2-m5C-ACLY轴通过素乙化介导的口路径促进肝细胞癌中伦瓦替尼的抗性

Shiguang Yang1,2, Jie Li3, Shengwei Mao1

  • 1Department of Hepatobiliary Surgery and Liver Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 19, 2025
PubMed
概括

通过向DNA甲基转移酶2 (DNMT2) 来克服肝癌 (HCC) 中对伦瓦提尼布的耐药性. 通过降低DNMT2的调节,通过抑制DNMT2-ACLY-NOTCH通路恢复敏感性,从而提供新的治疗策略.

关键词:
肝细胞癌是肝细胞癌.基因素乙化 基因素乙化 基因素乙化伦瓦提尼布耐药性 伦瓦提尼布耐药性m5C 修改的 修改

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