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与GRP94的ATM相互作用调节瘤受体表达和信号以及微质激活

Paige E Burrell1, Donald E Fleenor1, Olivia M Nicholson1

  • 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.

Proceedings of the National Academy of Sciences of the United States of America
|December 19, 2025
PubMed
概括

过敏性脑膜炎 (A-T) 研究揭示了ATM蛋白在DNA修复之外的新作用. ATM 调节 GRP94,影响细胞信号和微质激活,提供潜在的 A-T 治疗点.

关键词:
这是一个ATMATMATM.在 GRP94 中使用.巨细胞是一个巨细胞.微质细胞中的微质细胞受体氨酸激酶的受体.

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