纯母乳养在BAT中驱动AMPK依赖的热生成记忆,并促进后代的长期代谢益处
Ningxi Wu1,2, Anwen Yin3, Xiang Yu4
1Department of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Wuxi, Jiangsu, 214023, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 19, 2025
概括
纯母乳养通过通过一种新的信号通路编程棕色脂肪组织 (BAT) 热生成,从而防止肥胖. 这种代谢记忆提供了对代谢功能障碍的长期保护.
科学领域:
- 代谢编程是一种代谢编程.
- 肥胖研究的研究.
- 棕色脂肪组织生物学
背景情况:
- 纯母乳养与儿童肥胖风险降低有关,但机制尚不清楚.
- 配方养可能会对代谢健康产生负面影响.
- 棕色脂肪组织 (BAT) 在能量消耗和热生成中发挥着关键作用.
研究的目的:
- 阐明纯母乳养提供长期代谢保护的机制.
- 研究棕色脂肪组织 (BAT) 在调解这些益处中的作用.
- 确定关键的分子途径,参与母乳养诱导的代谢编程.
主要方法:
- 利用小鼠模型比较纯母乳养和混合配方养群体.
- 评估了BAT形态,线粒体功能和发热能力.
- 进行了转录基因分析和药理干预 (AMPK抑制,αKG补充).
- 研究了母乳衍生的细胞外囊泡和微RNAs (miR-125a-5p) 的作用.
主要成果:
- 混合配方养损害了BAT功能,并导致断奶后脂肪积累和葡萄糖不耐受性增加.
- 纯母乳养的小鼠表现出持续的BAT热能功能和代谢益处.
- 鉴定出HIF1AN/AMPK/αKG信号轴至关重要,AMPK激活是由母乳中的miR-125a-5p维持的.
- 在配方养小鼠中,α-谷氨酸 (αKG) 补充剂挽救了损坏的BAT功能.
结论:
- 纯母乳养通过HIF1AN/AMPK/αKG路径在BAT中建立了长期的"热能记忆".
- 这种印记赋予了对肥胖和葡萄糖不耐受性的显著代谢保护.
- 母乳成分,包括含有miR-125a-5p的细胞外囊泡,是这种保护作用的关键媒介.
更多相关视频
02:55Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
Published on: October 6, 2023
1.9K
05:04A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
814
相关概念视频
00:55Parental Care
12.6K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.6K
01:22Imprinting
10.8K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
10.8K