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相关概念视频

ATP Synthase: Structure01:18

ATP Synthase: Structure

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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

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ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
9.6K
ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
16.6K
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

4.6K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
4.6K
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.5K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
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Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
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收性甲状腺-ATPase相互作用调节了Danionella中的集体行为.

David Zada1, Mykola Kadobianskyi2, Benjamin Judkewitz2

  • 1Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 5290002, Israel.

Cell reports
|December 19, 2025
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概括

青少年,孤立或自闭症谱系障碍 (ASD) 模型中的社会行为障碍具有共同的遗传途径. 研究人员确定了KLF9和ATP1A1A.4等关键基因,揭示了调节社会相互作用的融合分子机制.

关键词:
亚太酶 ATPase 是一种酶.科普:神经科学是什么意思克里斯普尔是什么意思?克里斯普尔是什么意思?丹尼奥内拉 (Danionella) 是一个在RNAseqqq中使用.自闭症谱系障碍 自闭症谱系障碍集体行为就是集体行为.这就是KLF9的意义.甲状腺是什么?甲状腺是什么?

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Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin
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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 动物行为 动物行为

背景情况:

  • 在许多物种中,集体行为是基本的,它是从社会相互作用中产生的.
  • 在不成熟,社会孤立和遗传乱的动物中观察到社会行为缺陷,包括自闭症谱系障碍 (ASD) 模型.
  • 这些疾病中社会行为障碍的潜在遗传途径尚未完全理解.

研究的目的:

  • 为了调查丹尼奥内拉大脑中集体学校行为的遗传调节者.
  • 在不同条件下识别潜在的社会行为障碍的共同遗传路径.

主要方法:

  • RNA测序被应用于青少年,社会孤立的成年人和与ASD相关的基因脆的Danionella cerebrum的大脑.
  • 将基因表达特征与对照组进行了比较.
  • 用基因和药理学操纵来确认基因功能.

主要成果:

  • 一小组差异表达的基因在受损社会行为条件中是常见的.
  • 发现的关键基因包括参与甲状腺信号,昼夜节律,转录因子klf9和ATPase子单元atp1a1a.4.4的基因.
  • 功能性实验证实了这些基因在调节社会相互作用中的重要性.

结论:

  • 融合的分子通路调节社会互动和集体行为.
  • 共享的遗传机制有助于青少年,孤立和自闭症模型的社会行为缺陷.
  • 甲状腺信号传递,昼夜节律基因,KLF9和ATP1A1A.4是社会行为的重要调节者.