便微生物群的组成和功能与患有炎症性肠病的患者的焦虑和抑郁有关
Zhan Wang1, Minsi Zhou1, Yan Dang1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Diseases, Beijing, China.
PloS one
|December 19, 2025
概括
这项研究揭示了明显的肠道细菌和代谢变化在炎症性肠道疾病患者经历焦虑或抑郁. 这些发现突显了IBD精神病并发症中的肠-大脑轴连接.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 精神病学是一个精神病学.
背景情况:
- 炎症性肠病 (IBD) 越来越多地与焦虑和抑郁有关.
- 肠道微生物对大脑功能和心理健康的影响是一个日益增长的研究领域.
- 了解有精神症状的IBD患者的肠道微生物群变化至关重要.
研究的目的:
- 研究炎症性肠道疾病 (IBD) 患者的肠道微生物群的特征,这些患者也患有焦虑或抑郁症.
- 确定便微生物群组成和与这些并发病相关的功能差异.
主要方法:
- 使用医院焦虑和抑郁量表 (HADS) 评估焦虑和抑郁.
- 通过16S rRNA测序分析便微生物群组成.
- 使用液体染色学质谱法 (LC-MS) 检测到的便代谢物.
主要成果:
- 在患有焦虑和抑郁症的IBD患者中,观察到肠道微生物群的显著变化.
- 改变了特定的代谢途径,包括氨基酸降解和胆酸生物合成.
- 在患有焦虑症,抑郁症或两者的患者中,发现了特定细菌属和代谢物之间的相关性.
结论:
- 在焦虑或抑郁的IBD患者中,便微生物群的组成和功能发生了变化.
- 特定的细菌属和代谢物与IBD中的这些精神病并发症有关.
- 这些发现支持肠-大脑轴在IBD患者焦虑和抑郁的表现中的作用.
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