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在败血症中FLUid管理和个人化复苏 (FLUIDS) - 一个单中心,开放标签,随机临床试验的研究协议

Sanne Ter Horst^1,2, Ewoud Ter Avest¹, Jildou van Everdink²

¹Department of Acute Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

|December 19, 2025

概括

这项研究将使用中风体积指数 (SVI) 来个性化败血症复苏,以指导液体和血管压缩器. 预计SVI导向治疗将减少液体体积,并改善急诊室患者的治疗结果.

科学领域:

关键护理医学关键护理医学
心血管生理学心血管生理学
紧急医疗紧急医疗

背景情况:

败血症会导致复杂的血液动力学障碍,如血管扩张和低血压,需要迅速复苏.
目前在急诊室 (ED) 进行的液体管理缺乏个性化,影响了患者的耐受性和反应能力.
个性化复苏策略对于有效管理败血症至关重要.

研究的目的:

评估一个个性化的血液动力复苏策略,用于ED的败血症.
使用连续的非侵入性中风体积指数 (SVI) 测量以指导静脉注射 (IV) 流体治疗和血管压缩剂的启动.
为了比较SVI引导的复苏与标准护理在最初的治疗败血症.

主要方法:

一个单中心的,开放的,随机的临床试验,涉及188名疑似败血症的成年人.
患者随机分配到SVI指导干预组或标准护理控制组.
主要终点:在前三小时内注射的IV液体量;次要终点包括器官衰竭,死亡率和与液体相关的不良事件.

主要成果:

与标准护理相比,在SVI引导的复苏时,IV液体体积的预期减少.
个性化的方法旨在根据个体的血液动力学需求量身定制液体和血管压缩剂的管理.
在败血症管理中改善患者结局的潜力.

结论:

以SVI为指导的复苏为ED中败血症管理提供了个性化的方法.
这种策略可以优化液体和血管压缩剂的管理,从而有可能减少并发症.
需要进一步的研究来证实个性化血液动力学复苏在败血症的好处.

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