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Updated: Jan 8, 2026

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抗生素编辑的tRNA使得 COL4A5 早期终结子的翻译阅读成为可能

Kohei Omachi1,2, Joseph J Porter3, John D Lueck3,4,5

  • 1Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

PloS one
|December 19, 2025
PubMed
概括

抗生素编辑转移RNA (ACE-tRNAs) 在具有阿尔波特综合征无意义变异的细胞中成功恢复了全长的COL4A5蛋白表达. 这一突破为阿尔波特综合征提供了潜在的治疗策略,通过使必要的原IV蛋白链形成.

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