在乳腺癌患者中 (PLEDGE-Surgery) 带有或没有带有脉支流保护的关节切除产生的手术后上肢胀和功能障碍:一项随机对照研究
Xiangyun Zong1,2, Yang Yu3, Hongjian Yang3
1Department of Breast Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
International journal of surgery (London, England)
|December 19, 2025
概括
在骨淋巴结解剖 (ALND) 期间保护骨静脉支流可显著减少乳腺癌患者手术后上肢淋巴和功能障碍. 这种技术推用于接受ALND.患者.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 淋巴 edem 研究 研究 淋巴 edem 研究
背景情况:
- 在乳腺癌患者中,上肢淋巴和尾淋巴结解剖后功能障碍 (ALND) 的高发病率.
- 缺乏针对ALND后淋巴的有效预防策略.
研究的目的:
- 为了比较ALND带有或没有脉支流保护的效果.
- 评估对手术后上肢胀和功能障碍的影响.
主要方法:
- 多中心,前性,双盲,随机对照试验.
- 招募了258名女性患者 (乳腺癌II-III阶段) 需要ALND.
- 主要终点:术后短期上肢淋巴和功能障碍的发生率.
主要成果:
- 显著降低6个月 (0% vs. 10.78%) 和12个月 (2.38% vs. 16.18%) 淋巴 edem 的发病率与支流保存.
- 在干预组中,手臂,肩膀和手的残疾 (DASH) 得分的平均值较低.
- 保护下静脉支流被认为是预防手术后胀的保护因素.
结论:
- 带着骨静脉支流的保存进行骨淋巴结解剖 (ALND) 是有益的.
- 减少短期的术后上肢胀和功能障碍.
- 推用于需要ALND的乳腺癌患者.
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