肠道敏感性概况:在绝望中寻找希望
Ali Sufyan1, Hameer Saif Talpur1, Fiza Shafi1
1Department of General Medicine, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
肠热中抗菌素耐药性是令人担忧的,在患者中观察到大量的多药性耐药性和广泛的耐药性. 这凸显了更新治疗指南和对沙门氏菌 Typhi 感染的监测的迫切需要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 主要由沙门氏菌Typhi引起的肠热,对全球健康构成重大负担.
- 抗菌素耐药性是一个越来越大的问题,复杂的治疗和增加发病率和死亡率.
- 第三级护理机构经常管理具有耐药病原体的复杂病例.
研究的目的:
- 为了确定肠炎患者的抗微生物敏感性概况.
- 评估沙门氏菌中多抗药性 (MDR),广泛抗药性 (XDR) 和扩展谱β-乳糖酶 (ESBL) 生产的发生率.
- 评估对第一,第二和第三线抗菌剂的耐药性模式.
主要方法:
- 在伊斯兰堡的巴基斯坦医学科学研究所进行了一项回顾性研究.
- 从2019年1月到2023年4月的数据包括12岁以上的患者,血液培养确认了沙门氏菌Typhi.
- 分析了抗微生物敏感性测试结果,包括MDR,XDR和ESBL状态.
主要成果:
- 在734名患者中,11.98%的患者表现出多药性耐药性,24.25%的患者表现出广泛的耐药性.
- 在6.81%的病例中检测到扩展谱β-乳糖酶的产生.
- 虽然对第三线药物的敏感性很高 (99.2%),但对一线 (37.4%) 和二线 (30.5%) 药物的显著耐药性.
结论:
- 这项研究揭示了肠炎患者抗微生物药物耐药性的惊人水平.
- 高水平的MDR和XDR需要紧急关注,并可能修订治疗方案.
- 持续监测抗菌素敏感性对于有效管理肠炎至关重要.
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