社区顾问对喘治疗随机实用临床试验的影响:回顾性分析
Wilson D Pace1, Barbara Yawn2, Nancy E Maher3
1DARTNet Institute, 12635 East Montview Boulevard, Mail Stop 3, Aurora, CO, 80045, United States, 1 (800) 434-0278.
Journal of participatory medicine
|December 19, 2025
概括
社区顾问通过解决低调查响应率和增加吸入性皮质类固醇 (ICS) 使用,提高了临床试验的成功率. 他们的投入提高了患者的参与度和对喘治疗方案的坚持.
科学领域:
- 临床研究 临床研究
- 患者参与 患者参与
- 喘管理 喘管理
背景情况:
- 社区顾问是指导临床研究的重要合作伙伴.
- 关于社区参与对研究结果的影响的证据有限.
研究的目的:
- 描述社区顾问的意见如何影响临床试验的变化.
- 为了解决在试验实施过程中发现的特定问题.
主要方法:
- 使用了PREPARE随机临床试验的数据.
- 检查了社区顾问建议的协议修改.
- 专注于提高调查响应率和吸入性皮质类固醇 (ICS) 的使用.
主要成果:
- 协议变化显著增加了每月调查响应率,从67%增加到92%以上.
- 在干预后,吸入性皮质类固醇 (ICS) 与雾化剂治疗的使用量从42.1%增加到75.4%.
- 社区顾问的投入直接解决了关键研究实施的挑战.
结论:
- 社区驱动的协议变化对调查参与产生了积极影响.
- 辅导辅导干预改善了对喘药物治疗方案的遵守.
- 社区参与有效地提高了临床试验的进行和结果.
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