维生素E和认知功能:临床证据的系统审查
1Department of Clinical Pharmacy, Faculty of Pharmacy, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Nutrition research (New York, N.Y.)
|December 19, 2025
概括
维生素E,特别是来自饮食或多种维生素的维生素E,可能会防止认知障碍 (CI). 对于CI预防,需要对特定的维生素E形式 (如托克醇) 进行进一步的研究.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 认知障碍 (CI) 是阿尔茨海默病 (AD) 的一个主要挑战.
- 目前的AD治疗主要是治疗症状,预防认知能力下降的选择有限.
- 像维生素E这样的抗氧化剂正在研究它们对CI的潜在保护作用.
研究的目的:
- 系统地审查和评估关于维生素E在认知功能中的作用的证据.
- 评估对维生素E补充剂,饮食摄入量和含有维生素E的多维生素的研究.
- 确定有关特定维生素E异型和CI的研究缺口.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane图书馆 (2012-2022) 的系统文献搜索.
- 遵守PRISMA指南的研究选择和数据提取.
- 符合条件的研究分为三个类别:维生素E补充剂,食维生素E和含有维生素E的多维生素.
主要成果:
- 总共包括了43项临床研究,共有80,488名参与者.
- 其中1项研究涉及维生素E补充剂,18项研究涉及饮食维生素E,24项研究涉及含有维生素E的多种维生素.
- 维生素E,特别是来自饮食或多种维生素的维生素E,显示与对CI的保护作用有关.
结论:
- 摄入维生素E,特别是作为饮食或多维生素的一部分,似乎可以防止认知障碍.
- 与其他饮食或多维生素成分的协同效应可能会调解这种保护作用.
- 关于特定的维生素E异形 (托科特里诺,非α-托科菲罗) 和它们对CI的影响的研究有限,需要进一步调查.
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