复发的风险在病态阶段II-IIIA非小细胞肺癌没有淋巴结转移的淋巴结转移
Ryusuke Sumiya1, Takeshi Matsunaga1, Yukio Watanabe1
1Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, 113-8421, Japan.
Respiratory investigation
|December 19, 2025
概括
血管侵袭是肺癌复发的重要风险因素,在没有淋巴结转移的II-IIIA阶段非小细胞肺癌 (NSCLC) 患者中. 没有血管侵袭的患者表现出良好的预后,五年复发率为21.5%.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 癌症研究 癌症研究
背景情况:
- 辅助化疗,包括双剂,对于切除的II-III期非小细胞肺癌 (NSCLC) 是标准的.
- 在没有淋巴结转移的NSCLC患者中确定复发风险对于治疗分层至关重要.
研究的目的:
- 为了确定在没有淋巴结转移的切除II-IIIA阶段NSCLC患者的瘤结果的预后因素.
- 根据该患者队列中的病理因素评估复发风险.
主要方法:
- 对112名患有p-Stage II-IIIA NSCLC的患者进行了回顾性分析,这些患者接受了肺切除和中枢淋巴结剖析 (2009-2018).
- 排除标准包括先前的肺癌病史和术后化疗.
- 多变量分析和格雷测试被用来确定预后因素和复发率.
主要成果:
- 血管侵袭 (HR, 2.481) 和病态T因子 (HR, 1.819) 是无疾病生存的独立风险因素.
- 在患有血管侵袭的患者中,5年累计复发的发生率明显高 (37.5%) 与没有血管侵袭的患者相比 (21.5%,P=0.03).
结论:
- 血管侵袭是肺癌复发的重要预测因素,在没有淋巴结转移的II-IIIA阶段NSCLC患者中.
- 没有血管侵袭的患者表现出有利的预后,其5年复发率较低.
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