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相关概念视频

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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相关实验视频

Updated: Jan 8, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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甲状腺血管肉瘤:一个全面的审查

Giorgia Arcovito1, Alessandro Franchi1

  • 1Section of Anatomic Pathology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Seminars in diagnostic pathology
|December 19, 2025
PubMed
概括
此摘要是机器生成的。

甲状腺血管瘤 (TAS) 是一种罕见且具有攻击性的血管瘤. 需要进一步的研究,以了解其分子特征,并改进治疗策略,以应对这种具有挑战性的癌症.

关键词:
无塑性癌细胞瘤 (Anaplastic carcinoma) 是一种无塑性癌细胞.血管肉瘤是一种血管肉瘤.细胞学 细胞学流行病学 流行病学组织病理学 组织病理学免疫组织化学 免疫组织化学分子遗传学 分子遗传学甲状腺是什么?甲状腺是什么?

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科学领域:

  • 在瘤学瘤学.
  • 病理学 病理学 病理学
  • 遗传学 遗传学 是一个

背景情况:

  • 甲状腺血管瘤 (TAS) 是一种侵略性的血管瘤,占甲状腺介质瘤的20%.
  • TAS主要影响老年人,并且经常与长期的有关,特别是在缺地区.

研究的目的:

  • 审查甲状腺血管肉瘤的临床病理和遗传特征.
  • 突出诊断挑战,并确定潜在的治疗目标.

主要方法:

  • 对组织学和免疫组织化学发现的审查.
  • 对TAS所涉及的遗传变化和分子途径的分析.
  • 与类似的实体进行比较,例如血管形形癌.

主要成果:

  • 在TAS中,表现出具有严重形的上皮细胞,血管间隙,纤维化层,血红蛋白和.
  • 免疫组织化学显示CD31,ERG,XVIII因子,通常是细胞激素的阳性;PAX8和TTF-1是负的.
  • 遗传分析显示血管生成,增殖和生存基因 (例如MYC,KDR) 的损害以及PI3K/AKT/mTOR和MAP激酶通路的失调.

结论:

  • 准确的TAS诊断需要仔细整合组织学,免疫组织化学和分子数据.
  • 了解TAS的遗传情景对于开发新型治疗策略至关重要.
  • 进一步的分子研究对于充分描述TAS和改善患者的治疗结果至关重要.