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循环的瘤细胞预测头部和部粘膜状细胞癌的复发

Dannel Yeo¹, Xiaoqi Liang², Althea Bastian³

¹Li Ka Shing Cell & Gene Therapy Program, The University of Sydney, Camperdown, New South Wales, Australia; Precision Oncology Laboratory, Cancer Innovations, Centenary Institute, Camperdown, New South Wales, Australia; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Sydney Local Health District, Camperdown, New South Wales, Australia.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|December 19, 2025

概括

在头部和部粘膜状细胞癌 (HNmSCC) 患者中检测循环瘤细胞 (CTC) 显示出独立的预后价值. 高CTC水平预测复发,有助于个性化治疗的风险分层.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
癌症研究癌症研究

背景情况:

头癌 (HNC) 是一个全球性的健康挑战,常常在地方或地区复发.
循环瘤细胞 (CTC) 正在成为各种固体瘤中关键的预后生物标志物.
头部和部粘膜状细胞癌 (HNmSCC) 是一种普遍的亚型,需要改进复发预测.

研究的目的:

在HNmSCC.患者中检测和列举循环瘤细胞 (CTC).
评估CTCs对预测癌症复发的预后意义.
评估CTC作为HNmSCC管理中的生物标记物的实用性.

主要方法:

预期招募接受手术切除的HNC患者.
使用AccuCyte-CyteFinder平台对CTC进行术前和术后外周血液样本分析.
预后性能通过多变量逻辑回归,ROC分析和无复发生存分析来评估.

主要成果:

在81%的HNmSCC患者 (46/57) 中检测到CTC,平均每7.5毫升血液中有19个CTC.
术前切线≥5个CTC (CTC高状态) 与复发 (OR=9.52,p=0.022) 和较差的无复发存活率 (p=0.016) 显著相关.
在多变量分析中,CTC高状态仍然是复发的独立预测因素 (aOR=8-10),补充了边际参与 (aOR=6.17,p=0.024). 手术后的CTC也预测了复发 (OR=26.71,p=0.0009).

结论:

通过AccuCyte-CyteFinder检测到的CTC在HNmSCC中提供了独立的预后值.
术前CTC列举可以增强风险分层,用于识别患有复发高风险的患者.
这种方法补充了传统的病理学,可能引导个性化的监测和治疗策略.

关键词:

生物标志物生物标志物液体活检液体活检口腔癌是一种口腔癌.精准医学是一门精准的医学.预测预后预测预测风险分层是指风险的分层.

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