环境污染物和上腺类固醇在老年人中的生物合成
Mark M Kushnir1, Samira Salihovic2, Jonas Bergquist3
1ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, United States of America; Department of Pathology, University of Utah, Salt Lake City, UT, United States of America.
The Science of the total environment
|December 19, 2025
概括
环境污染物 (ECs) 与老年人的上腺类固醇 (AS) 水平有关. 孕醇 (Pregn) 与ECs的关联最强,而皮质醇的影响最小.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 以前的研究将环境污染物 (EC) 与老年人的性激素联系起来.
- 这项研究研究了四类EC和五种上腺类固醇 (AS) 之间的关联,包括皮质醇及其前体.
研究的目的:
- 研究老年人血液中各种环境污染物的度与上腺类固醇水平之间的关系.
- 探索因EC暴露而影响上腺类固醇生物合成的潜在结构-活性关系.
主要方法:
- 来自乌普萨拉老年人血管前性调查 (PIVUS) 研究的950名老年人 (70岁) 的血样本的分析.
- 四种上腺类固醇的量化 (孕诺,17-基孕诺,17-基孕,11-脱氧皮质醇) 和皮质醇.
- 使用质谱和ELISA测量了21种持久性有机污染物 (POP),8种 perfluoroalkyl物质 (PFAS),4种甲酸盐和10种金属.
主要成果:
- 所有类别的环境污染物都显示出与上腺类固醇度的复杂关联.
- 孕 (Pregn) 与ECs的关联最强;皮质醇受到影响最少.
- 在Pregn,17-hydroxyprogesterone和17-hydroxy pregnenolone以及特定的PCB,甲酸盐和金属 (Al,Cd,Cu,Hg,Ni) 之间观察到最强的关系,女性的效果更强.
结论:
- 老年人表现出许多环境污染物的度和皮质醇通路内的上腺类固醇之间的关联.
- 这些EC-AS关系对与上腺类固醇生物合成相关的疾病的临床影响需要进一步研究.
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