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Updated: Jan 8, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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转录重启:PARylation在克服DNA损伤方面的新作用

Jingwei Liu1, Xiaoyu Song1, Liu Cao2

  • 1The College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China; Key Laboratory of Cell Biology of Ministry of Public Health, Key Laboratory of Medical Cell Biology of Ministry of Education, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, Shenyang, Liaoning Province 110122, China.

Cell chemical biology
|December 19, 2025
PubMed
概括

新发现的多 (ADP-ribose) 聚合酶1 (PARP1) 能够重新启动转录. 这种酶稳定了AFF1以促进DNA损伤后的转录恢复,扩大其已知的功能.

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