前列腺癌
Valérie Fonteyne1, Alison Tree2, Elena Castro3
1Department of Radiotherapy-Oncology, Ghent University Hospital, Ghent, Belgium.
Lancet (London, England)
|December 19, 2025
概括
前列腺癌的治疗方法有了显著的进步, 新的全身疗法,包括针对性药物,可用于晚期疾病,并与已知的治疗方法和积极的监测.
科学领域:
- 癌症学
- 尿道病学
背景情况:
- 前列腺癌是全球癌症相关死亡的主要原因.
- 最近的进展改变了前列腺癌的治疗策略.
- 了解当前的治疗选择对于患者的管理至关重要.
研究的目的:
- 审查前列腺癌的病理学,诊断和治疗方法.
- 为了突出不断发展的治疗场景.
- 为前列腺癌患者的临床决策提供信息.
主要方法:
- 关于前列腺癌病理学,诊断和治疗的文献综述.
- 分析当前和新兴的治疗方式.
- 根据疾病阶段和患者因素进行治疗选择的讨论.
主要成果:
- 建议积极监测缓慢的前列腺癌.
- 局部治疗对于局部疾病是有效的.
- 系统性治疗,包括抗雄激素治疗,化疗和新药,如Lu-177-PSMA放射性治疗和PARP抑制剂,对于晚期和转移性前列腺癌至关重要.
结论:
- 考虑毒性和患者偏好的共同决策至关重要.
- 需要进一步研究以优化转移性前列腺癌的治疗序列和组合.
- 治疗前列腺癌的方法正在不断发展,
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