动脉壁组织力学构成模型的进展:从理论框架到临床应用
Qian Fan1, Dezhong Qi2, Qiang Xiao1
1Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 27100, China.
Progress in biophysics and molecular biology
|December 19, 2025
概括
本综述检查了动脉壁组织 (AWT) 机制的组成模型,这对于理解心血管疾病 (CVD) 至关重要. 弹性,粘弹性和生长模型的进步改善了血管行为的预测,并为临床实践提供了信息.
科学领域:
- 生物力学和机械生物学
- 计算型固体力学 计算型固体力学
- 生物医学工程 生物医学工程
背景情况:
- 心血管疾病 (CVD) 是一个主要的全球健康问题.
- 动脉壁组织 (AWT) 机械行为是心血管疾病发展和进展的组成部分.
- 了解血管力学是改善心血管疾病诊断和治疗的关键.
研究的目的:
- 审查过去二十年来AWT构成模型的进步.
- 提高对血管力学的理解,并为临床实践提供信息.
- 评估用于建模AWT行为的计算框架.
主要方法:
- 调查了五个主要的计算框架:弹性,粘弹性,超弹性,结构固体和生长和重塑 (G&R) 模型.
- 评估模型捕捉压力-应变关系和机械生物学相互作用的能力.
- 分析模型适合生理和病理条件的分析,包括大变形,异构和时间依赖的反应.
主要成果:
- 简单的弹性模型对AWT的非线性不够;非线性和伪弹性模型更好地处理大变形和异构.
- 粘弹性模型准确地代表了对脉动性血流的时间依赖反应.
- 结构固体模型提供了单个壁层机制的高保真性预测,而G&R模型模拟了长期适应改变的血液动力学.
结论:
- AWT的构成模型已经取得了显著的进步,从基本弹性到复杂的G&R框架.
- 未来的研究应该专注于动态,多尺度和多物理模型,整合大数据和机器学习.
- 改进的AWT建模对于推进个性化医学和深化对心血管疾病机制的理解至关重要.
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