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在巴西野地消防员中,氧化DNA损伤和PAH暴露之间存在关联

Rafael Araújo Silva¹, André Augusto Vilela Lima², Rodrigo Severo Caixeta³

¹Laboratory of Analysis of Toxicants and Drugs, Faculty of Pharmacy, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil; Minas Gerais Military Fire Department (CBMMG), Belo Horizonte, Minas Gerais, Brazil.

Environmental pollution (Barking, Essex : 1987)

|December 19, 2025

概括

野生地区的消防员面临着致癌的多环芳 (PAHs) 的高暴露. 这项研究发现,巴西消防员暴露在PAH和氧化DNA损伤之间存在强烈的联系,突出了紧急的安全需求.

科学领域:

环境健康环境健康
职业健康职业健康职业健康
生物监测生物监测

背景情况:

野生地区的消防员接触到致癌物质,如烟雾中的多环芳香 (PAH).
不充分的呼吸道保护加剧了暴露风险.
对PAH暴露和早期生物效应之间的关联知之甚少,这复杂化了风险管理.

研究的目的:

评估巴西野地消防员的多环芳 (PAH) 暴露水平.
调查PAH暴露和氧化DNA损伤之间的关系.
确定8-基-2'-脱氧氨酸 (8-OHdG) 作为这种职业风险的生物标志物的实用性.

主要方法:

一项涉及84名巴西男性消防员 (42名操作,42名行政) 的横截面研究.
使用质谱学量化尿中PAH代谢物 (OH-PAH) 和8-基-2'-脱氧氨酸 (8-OHdG) 的量化.
通过问卷收集数据,并与ACGIH生物暴露指数进行比较.

主要成果:

暴露组表现出尿道总OH-PAHs (6.6倍) 和8-OHdG (3.3倍) 的水平显著更高.
中位数的1-西水平是已确定的生物暴露指数的15倍.
在总PAH负担和氧化DNA损伤之间观察到强烈的正相关性 (r=0.72,p<0.001).

结论:

这项研究提供了关于巴西野地消防员PAH暴露和DNA损伤的开创性生物监测数据.
结果表明暴露水平令人担忧,并验证了8-OHdG作为影响的相关生物标志物.
需要加强安全标准和个人防护设备,以减轻野地消防员的健康风险.

关键词:

评估健康风险评估健康风险人类生物监测人类生物监测职业健康职业健康职业健康职业健康多环芳香碳化合物多环芳香碳化合物野生地区的消防员.

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