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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
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针对黄热病病毒:对NS1蛋白的特定合体的开发

Mariane Izabella Abreu de Melo1, Alessandra Nunes Duarte Miranda1, Antero Silva Ribeiro de Andrade1

  • 1Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Programa de Pós-Graduação em Ciência e Tecnologia das Radiações, Minerais e Materiais, Belo Horizonte, MG, Brazil.

Journal of virological methods
|December 19, 2025
PubMed
概括

一种新的DNA吸附体,Flav5,对黄热病病毒 (YFV) NS1蛋白具有很高的特异性和亲和力. 这一发展为准确的YFV诊断提供了有前途的工具,特别是在其他状病毒流通的地方.

关键词:
亚普特美尔 (Aptamer) 是一种药物.在CE-SELEXEX中使用.诊断 诊断 诊断 诊断 诊断在 NS1 蛋白质中,NS1 是一种蛋白质.黄热病病毒 黄热病病毒

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Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...