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使用小鼠和子肠道有机体对DS-2087b诱导的胃肠道毒性进行物种间差异的评估

Yuji Shirai1, Takuma Iguchi1, Kazunori Fujimoto1

  • 1Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan.

Toxicology letters
|December 19, 2025
PubMed
概括

动物小肠器官有效预测体内药物诱导的胃肠毒性. 子有机体显示细胞活力下降和基因表达改变,解释了从DS-2087b.中毒性的物种间差异.

关键词:
这是一只Cynomolgus子.这是一种EGFR抑制剂.胃肠道毒性 胃肠道毒性肠道有机物 肠道有机物帕内特细胞是帕内特细胞.转录组 转录组就是一个转录组.

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