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侧隔膜中的HCN通道抑制剂ZD7288减弱了甲基胺诱导的行为敏感化和复发

Shishi Lai1, Wenpei Zhang2, Cailing Wang3

  • 1Yunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan University, Kunming, 650091, China; Shenzhen Key Laboratory of Drug Addiction, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; Shenzhen Neher Neural Plasticity Laboratory, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; Yunnan University, Kunming, 650091, China; Southwest United Graduate School, Kunming, 650092, China.

Neuropharmacology
|December 19, 2025
PubMed
概括

使用ZD7288准横隔膜 (LS) 中的高极化激活的循环核酸门 (HCN) 通道,可以减少甲基胺成行为. 这种方法使神经元活动正常化,而不会影响自然奖励.

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