初级甲状腺功能障碍症与冠状动脉分数升高和心血管风险增加有关
Justin S Bauzon1, Gustavo Romero-Velez2, Jay Ramchand3
1Department of Endocrine Surgery, Cleveland Clinic, Cleveland, OH, USA.
概括
原发性偏甲状腺症 (PHPT) 与较高的冠状动脉 (CAC) 评分有关,这表明心血管风险增加. 患有PHPT和更长时间未经治疗的疾病持续时间的男性表现出更大的化,这表明查是有必要的.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 原发性偏甲状腺症 (PHPT) 与心血管风险增加有关.
- 冠状动脉 (CAC) 评分量化了心血管风险评估的性斑块负担.
- 在PHPT和CAC得分之间的关系仍然未被充分探索.
研究的目的:
- 评估PHPT和CAC分数之间的关联.
- 确定PHPT是否可以独立预测冠状动脉化.
- 在PHPT患者中探索心血管风险分层.
主要方法:
- 对415名接受CAC评分的患者 (2015-2024) 的回顾性分析.
- 纳入标准:在CAC测试后一年内,同步的血清和副甲状腺激素水平.
- 在PHPT和非PHPT组之间比较CAC得分 (低中等:0-99,高:≥100);根据风险和PHPT亚型对子组进行分析.
主要成果:
- 与非PHPT患者相比,PHPT患者的高CAC分数 (≥100) 的患病率较高 (67%与50%相比,p=.04).
- PHPT独立地预测了高的CAC得分 (OR 1.5,p=.03).
- 男性PHPT患者的CAC得分明显高于女性 (中位数为495比6,p<.01);长时间未经治疗的PHPT与严重化相关 (OR1.2,p<.01).
结论:
- PHPT与冠状动脉体负荷增加和心血管事件风险增加有关.
- 男性的性别和未经治疗的PHPT的更长时间与更大的冠状动脉化有关.
- 常规CAC查可能有利于PHPT人群进行心血管风险评估.
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