对基于的性别确认疗法的年龄依赖性肌肉反应:来自1年观察性研究的证据
Chiara Ceolin1, Sandro Savino2, Caterina Gregorio3
1Geriatrics Division, University of Padua, Padua, Italy; Department of Medicine (DIMED), University of Padua, Padua, Italy; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Aging Research Center, Stockholm, Sweden.
概括
年龄显著影响跨性别者的丸激素治疗肌肉增长. 年轻的成年人体验到更大的力量和肌肉质量增加,相比较于年长的个人开始性别肯定激素治疗.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 跨性别者健康 跨性别者健康
背景情况:
- 了解与丸激素治疗的年龄相关反应对于跨性别和性别多元的人来说至关重要,在出生时被分配为女性 (TGD AFAB).
- 以前的研究还没有完全阐明年龄如何影响肌肉适应性别肯定激素治疗 (GAHT).
研究的目的:
- 为了研究接受丸激素治疗的TGD AFAB个体肌肉力量和质量的1年变化.
- 检查对基于的GAHT反应的年龄特异性差异.
主要方法:
- 一项前性纵向观察性研究招募了107名TGD AFAB成年人.
- 参与者分为各个年龄组 (20-24,25-29,30-34,≥35岁),并在基线和12个月评估手握强度和身体组成 (双能X射线吸收计).
- 线性混合模型和定量回归分析了群体内的变化和与年龄相关的趋势.
主要成果:
- 在所有年龄组中,手握强度都增加了,在年轻参与者 (25-29岁和20-24岁) 中观察到的最显著的增长.
- 肌肉质量 (尾骨肌肉质量指数) 在年轻人中略有增加,从30岁起停滞或下降.
- 30-34岁的年龄组表现出肌肉质量下降,特别明显在第25个百分点.
结论:
- 个体开始丸激素治疗的年龄显著影响肌肉适应.
- 力量的增长在成年早期更为明显,随着年龄的增长而减少.
- 这些发现可以为TGD AFAB患者提供适合年龄的临床咨询,以启动激素治疗.
相关概念视频
Signs of Puberty
1.3K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.3K
Testosterone: Functions and Regulation
2.0K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.0K
Menopause
3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
The Y Chromosome Determines Maleness
7.8K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
7.8K
Socioemotional Experience and Gender Development
250
Social-emotional experiences and cultural influences play significant roles in shaping gender development. During middle childhood, from ages 6 to 11, peer groups become dominant in reinforcing gender norms. Children in this age group often align with same-gender peer groups, which actively encourage behaviors that conform to traditional gender roles. For instance, boys may be discouraged from engaging in activities perceived as feminine, reinforcing culturally dictated norms about masculinity...
250


