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在细胞生殖细胞瘤中没有生长激素的生长:临床特征和预测因素

Tao Tong¹, Caiyan Mo¹, Hongyu Liu¹

¹Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|December 19, 2025

概括

在患有细胞生殖细胞瘤 (GCTs) 和生长激素缺乏 (GHD) 的儿童中,没有生长激素 (GWGH) 的生长与肥胖和更高的禁食胰岛素水平有关. 胰岛素水平升高可能部分解释了这种现象,需要进一步调查.

科学领域:

儿科内分泌学儿科内分泌学
在瘤学瘤学.
代谢障碍代谢障碍代谢障碍

背景情况:

细胞生殖细胞瘤 (GCTs) 经常导致儿童生长激素缺乏 (GHD) 和生长障碍.
一部分患有GHD的儿童表现出接近正常的生长,称为没有生长激素 (GWGH) 的生长,其机制尚不清楚.

研究的目的:

研究细胞生殖细胞瘤 (GCTs) 和生长激素缺乏症 (GHD) 的儿科患者没有生长激素 (GWGH) 的生长的临床特征和预测因子.

主要方法:

一项回顾性研究包括130名患有细胞GCT和GHD的儿科患者.
年增长≥5厘米的患者被归类为GWGH (n=15),与1:2匹配的非GWGH对照组相比.
分析了临床数据,垂体功能,激素治疗,下丘脑综合征和禁食胰岛素水平;物流回归确定了GWGH预测因子.

主要成果:

11.5%的患者表现出GWGH,其特点是肥胖增加,瘤变大,以及更大的下丘脑参与.
两组之间在垂体功能障碍或激素替代疗法方面没有发现显著差异.
在GWGH患者中,禁食胰岛素水平显著更高 (22.58 ± 8.76 vs 7.41 ± 4.38 μIU/mL,p < 0.001),禁食胰岛素水平升高被确定为独立预测因子 (OR = 1.61,p = 0.006).

结论:

没有生长激素 (GWGH) 的生长发生在11.5%的患有GHD的儿科细胞GCT中,与下丘脑参与,肥胖和高胰岛素血症有关.
增加的禁食胰岛素可能会导致GWGH,这表明胰岛素在生长调节中可能发挥作用,尽管GHD.
需要进一步的前性研究来阐明GWGH背后的精确机制.

关键词:

没有生长激素的增长.生长激素缺乏,生长激素缺乏.过高胰岛素血症的发生脑下垂体功能障碍是什么细胞胚胎细胞瘤细胞胚胎细胞瘤

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