通过aDNA分析首次证实了中世纪爱尔兰的Mycobacterium结核病综合体 - - 古病理学和微生物发现
Eileen M Murphy1, G Michael Taylor2, Tom A Mendum2
1Archaeology and Palaeoecology, School of Natural and Built Environment, Queen's University Belfast, Belfast, BT7 1NN, Northern Ireland, UK.
Tuberculosis (Edinburgh, Scotland)
|December 19, 2025
概括
古代DNA (aDNA) 测试证实了爱尔兰定居点的五个人感染了结核病. 这项研究为爱尔兰的考古学家提供了第一个aDNA结核病的证据.
科学领域:
- 古病理学 古病理学
- 古代DNA分析 古代DNA分析
- 传染病流行病学 传染病流行病学
背景情况:
- 来自爱尔兰兰莱纳的八个葬礼中的古病理病变表明骨结核病或乳头结核病.
- 这个地点是一个多时期的农村定居点,靠近罗斯科蒙镇.
研究的目的:
- 通过使用古老DNA (aDNA) 分析,确认或反驳结核病和甲状腺素病在具有暗示骨病变的个体中的存在.
- 为了确定特定的病原体及其血统,如果结核病被证实.
主要方法:
- 古代DNA (aDNA) 从八个个体的牙髓腔中提取.
- 聚合酶连锁反应 (PCR) 放大和测序针对Mycobacterium结核复合体 (MTB) 和布鲁塞拉物种DNA.
- 对古病理病变的分析,包括脊椎脊椎的形病变.
主要成果:
- 结核感染 (MTB复杂DNA) 在5名个人中得到证实,这些人来自公元7世纪至13世纪.
- 在两个阳性病例中,鉴定了Mycobacterium结核病系4 (欧美) DNA.
- 所有被测试的个体,包括一个患有突菌病变的个体,都对布鲁塞拉物种DNA呈阴性.
结论:
- 古代DNA分析证实了来自爱尔兰Ranelagh的五个人患有结核病,这代表了爱尔兰考古遗迹中这种疾病的第一个aDNA证据.
- 这些发现强调了在中世纪早期和中世纪时期爱尔兰的结核病存在.
- 这项研究证明了aDNA在诊断古代传染病和区分类似病理方面的实用性.
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