利用患者的自流来改变结核病的治疗方法
Naomi Okugbeni1, Victoria Cole2, Elouise Kroon3
1South African Medical Research Council Genomics Platform, Tygerberg, South Africa; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
结核病患者的自流量分析对于开发有效的宿主导疗法 (HDT) 至关重要. 这篇评论强调了其作为诊断,预后和个性化治疗策略的生物标志物的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 构成了重大的全球卫生挑战,推动了对宿主导治疗 (HDT) 的研究.
- 自,免疫和病原体清除的关键细胞过程,是结核病中HTT的关键目标.
- 目前针对自的治疗方法的临床转化受限于对患者特异性自动态的理解不足.
研究的目的:
- 突出患者自流的重要性,作为结核病中自活动的定量衡量标准.
- 为了强调自流作为结核病研究和临床应用中的生物标志物的不足利用.
- 建议将自流量评估整合到针对结核病的个性化HDT策略中.
主要方法:
- 对结核病中自机制的现有文献的综述.
- 检查患者衍生样本中自流量评估的方法.
- 对结核病的自细胞向干预措施的临床前和临床数据的分析.
主要成果:
- 自流是结核病患者细胞反应的动态和定量指标.
- 现有的自流量评估方法提供了有价值的见解,但需要为临床使用标准化.
- 基于自流的患者分层可以实现量身定制的治疗方法.
结论:
- 准确地描述患者衍生的自流是促进结核病宿主导治疗的必要条件.
- 自流作为结核病诊断,预后和个性化治疗选择的有希望的生物标志物.
- 自流的标准化评估可以弥合结核病中自调节策略的临床前承诺和临床疗效之间的差距.
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