预氧化与高流量鼻氧在选择性手术患者的各种流速:一个前性的,随机的,单盲临床试验
Albin Sjöblom1, Frida Hoffman1, Magnus Hedberg1
1Karolinska University Hospital, Stockholm, Sweden; Karolinska Institutet, Stockholm, Sweden.
British journal of anaesthesia
|December 19, 2025
概括
高流量鼻氧 (HFNO) 预氧化在45L分钟-1提供与更高率 (70-95L分钟-1) 相比的安全呼吸暂停时间,患者的不适较小. 这表明45L分钟-1是临床氧化前的有效和舒适选择.
科学领域:
- 麻醉学 麻醉学
- 临界护理医学 临界护理医学
- 呼吸系统疗法 呼吸系统疗法
背景情况:
- 高流量鼻氧 (HFNO) 越来越多地用于手术患者的先氧化.
- 之前对HFNO氧化前的研究集中在低于60L分钟-1的流速上.
- 对于氧化前的最佳HFNO流速需要进一步的研究.
研究的目的:
- 为了比较在氧化前过程中不同HFNO流速 (45,70,和95 L min-1) 的有效性.
- 根据安全性和患者舒适性,确定最适合临床氧化前的HFNO流速.
主要方法:
- 一项随机试验,涉及72名接受选择性手术的患者 (ASA身体状况1-3).
- 预氧化通过HFNO随机流速进行:45,70,或95 L min-1 .
- 主要结局:呼吸暂停时间直到SpO达到93%;次要结局:PaO水平和与氧化前相关的不适.
主要成果:
- 在三个HFNO流速 (平均持续时间:472s,523s,483s) 中,无呼吸时间没有显著差异.
- 95 L min-1 组在呼吸暂停开始时显示出较高的 PaO,而 45 L min-1 组则显示出较高的 PaO,没有其他显著的 PaO 差异.
- 患者报告的不适程度在45L分钟-1时最低,而70和95L分钟-1时最低.
结论:
- 在45,70,和95L分钟-1的HFNO预氧化提供了可比的安全呼吸暂停时间.
- 45L分钟-1的流量提供了最少的不适,同时保持有效的氧化前期.
- 增加HFNO流速超过45L分钟-1不太可能显著延长安全的呼吸暂停时间.
相关概念视频
Oxygen Delivering System I: Nasal Cannula and Face Mask
1.3K
The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
1.3K
Administering Oxygen by Mask
1.9K
Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
1.9K
Administering Oxygen by Nasal Cannula
2.4K
Oxygen therapy is critical to patient care, especially for those struggling with respiratory issues. This intervention increases the oxygen concentration in the lungs, enhancing the amount of oxygen transported to the body's tissues. One standard method of delivering supplemental oxygen is through a nasal cannula, a non-invasive device that provides low to medium oxygen concentrations.
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
2.4K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
1.7K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.7K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
554
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
554
Oxygen Delivering System III: Tracheostomy and T-piece
5.2K
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
5.2K


