怀孕期间1型糖尿病妇女的后代的死亡率
Erik Somersalo1, Cedric Korpijaakko1, Mia D Eriksson1
1Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland.
Primary care diabetes
|December 19, 2025
概括
怀孕期间母亲1型糖尿病与30年内子女死亡风险增加1.67倍有关. 这种增加的风险与新生儿不良风险概况和特定死亡原因有关.
科学领域:
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕妇患有1型糖尿病的孕妇往往会导致胎儿和新生儿并发症.
- 糖尿病母亲的后代的长期健康结果需要进一步调查.
研究的目的:
- 为了确定怀孕期间母亲的1型糖尿病是否会影响后代的长期死亡率.
- 分析与孕产妇糖尿病状况相关的,出生后长达30年的死亡风险.
主要方法:
- 一项基于登记的后续研究,比较了1762名患有1型糖尿病的母亲的后代 (病例) 和8810名没有糖尿病的母亲的后代 (对照).
- 从1988年到2018年,通过芬兰统计局收集了死亡率数据 (时间和原因).
- 出生时的临床数据来自芬兰医疗出生登记册.
主要成果:
- 患有1型糖尿病的母亲的后代在30年随访期间死亡率高出1.67倍 (原始HR1.67 [95%CI:1.01-2.77]).
- 这些病例呈现出不良的新生儿风险概况.
- 在病例组内观察到内分泌,营养,代谢疾病和神经系统疾病的死亡率增加.
结论:
- 怀孕期间母亲的1型糖尿病与明显更高的后代死亡率有关.
- 这些发现强调了长期监测后代健康的重要性,因为孕期因母亲1型糖尿病而复杂.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Carbohydrate Metabolism
13.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.7K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Teratogenicity
3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K


