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Updated: Jan 8, 2026

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非共价PPARγ逆agonism的结构决定因素及其治疗影响

Kuang-Ting Kuo1,2, Bilel Bdiri2, Yuanjun He2

  • 1Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, La Jolla, CA, USA.

Nature communications
|December 19, 2025
PubMed
概括

研究人员开发了新的PPARγ类似物,可增强胰岛素敏感性,用于2型糖尿病治疗. 这些化合物表现出更好的结合和活性,为更安全的代谢疾病治疗提供了潜在的框架.

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
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