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空间损伤对称性对氧化B-DNA的结构反应的影响

Bahare Noohi1, Mansour Zahedi2

  • 1Department of Computational and Physical Chemistry, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, Iran. baharenoohi@gmail.com.

Scientific reports
|December 19, 2025
PubMed
概括

氧化应激会产生像8-基-2'-脱氧氨酸 (8-基-dG) 这样的DNA病变,影响DNA结构. 损伤位置,而不仅仅是发生,显著改变了DNA的稳定性和功能,这对于理解突变发生和基因组不稳定性至关重要.

关键词:
8-基-2′-脱氧氨酸 (8-基-dG)螺旋变形描述器的螺旋变形描述器氧化的B-DNA损伤反应分子动力学模拟的反应分子动力学模拟.病变的空间分布.

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